Cracking Addiction the Second Time Around: Reconsolidation of Drug-Related Memories
نویسندگان
چکیده
One of the greatest challenges in the understanding and treatment of addiction is cue-elicited relapse to drug use. The present findings of Miller and Marshall and Lee et al. reported in this issue of Neuron demonstrate that retrieved drug-related memories undergo reconsolidation and thus suggest that these maladaptive associations may be more labile than previously thought.
منابع مشابه
Addiction: a drug-induced disorder of memory reconsolidation.
Persistent maladaptive memories that maintain drug seeking and are resistant to extinction are a hallmark of addiction. As such, disruption of memory reconsolidation after retrieval has received attention for its therapeutic potential. Unrestrained reconsolidation may have the opposite effect, leading to reiterative and cumulative strengthening of memory over long periods of time. Here we revie...
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Memory reconsolidation — the process by which memories can become destabilised at retrieval, and be updated or modified — offers a potential therapeutic opportunity for mental health disorders based upon maladaptive emotional memories, such as drug addiction. Blocking the reconsolidation of pavlovian cue-drug memories persistently reduces subsequent relapse in rodent models and in human experim...
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Previously consolidated memories have the potential to enter a state of lability upon memory recall, during which time the memory can be altered before undergoing an additional consolidation-like process and being stored again as a long-term memory. Blocking reconsolidation of aberrant memories has been proposed as a potential treatment for psychiatric disorders including addiction. Here we inv...
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Long-lasting vulnerability to drug cue-induced relapse to a drug-taking habit is a major challenge to the treatment of drug addiction. Here we show that blockade of drug memory reconsolidation, through infusion of Zif268 antisense oligodeoxynucleotides into the basolateral amygdala shortly before reexposure to a cocaine-associated stimulus but not simply to the training context, severely impair...
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عنوان ژورنال:
- Neuron
دوره 47 شماره
صفحات -
تاریخ انتشار 2005